Category: Life Science

Employment Type: Contract

Reference: BH-374928

Research Scientist needed for a contract opportunity with Yoh Scientific's client located in San Diego, CA.

This position is for a major pharmaceutical company, and this position is a suitable for someone with automated liquid handling experience a plus.

Schedule: Monday through Friday, 1st shift.

Responsibilities

• Primary responsibility is to perform original research to develop marketable products.
• Special emphasis will be placed on automated antibody and bispecific purification, which will involve working with GE AKTA (Pure/Avant) and Unicorn software. Knowledge of Protein Maker instrument a plus.
• Generate mg to gram quantities of material for in-vivo efficacy studies.
• Develop and optimize high-throughput purification capabilities using Lynx900 and KingFisher Flex System.
• Packing of chromatography columns, operating endotoxin free chromatography, including operating preparative (FPLC) and analytical (HPLC) chromatography systems.
• Analytical characterization including endotoxin measurements, protein quantitation assays, analytical HPLC chromatography (HIC, SEC), capillary electrophoresis (CE-SDS and cIEF), DLS, and mass photometry.
• Buffer preparation, molar concentration quantitation and pH adjustment.
• Storing, inventorying, and ordering department supplies.
• Participates on cross-functional teams by performing assigned experiments and offering technical advice at team meetings; shares technical expertise with other colleagues; trains or provides guidance to other personnel, if needed.
• Maintain a neat and clean work environment.
• Manage your workload with minimal supervision.
• Collaborate and communicate with cross-functional teams.

• Bachelor's Degree 5+ years or Master's Degree 3+ years or PhD with no experience in Biochemistry, Molecular Biology, Bioengineering, Cell biology or related discipline.
• Experience in antibody/bi-specific purification and characterization including, but not limited to SDS-PAGE, CE-SDS, CiEF, AnSEC, endotoxin measurement, A280.
• Automated liquid handling a plus.
• Purification and characterization of bispecific antibodies.
• Experience with complex modalities.
• Sample inventory management.
• Exceptional organizational skills and attention to detail.
• Excellent time management skills and multi-tasking capabilities.
• Must be very detail-oriented and organized, with excellent time-management and multitasking skills.
• Have outstanding analytic and problem-solving abilities.

• Medical, Dental & Vision Benefits
• 401K Retirement Saving Plan
• Life & Disability Insurance
• Direct Deposit & weekly ePayroll
• Employee Discount Programs
• Referral Bonus Programs